inducible clindamycin resistance in clinical isolates of staphylococcus aureus
نویسندگان
چکیده
conclusions in our study, inducible clindamycin resistance rate was 4%; so it is necessary to conduct d-test regularly by disc diffusion for this bacterium. resistance to erythromycin, clindamycin, ciprofloxacin and gentamicin was significantly higher in mrsa isolates than methicillin susceptible staphylococcus aureus (mssa), although the methicillin resistance prevalence was low. background staphylococcus aureus is one of the most important agents causing nosocomial infections. inducible clindamycin resistance is an important concern, because, common laboratory tests could not detect it. objectives the aim of this study was to detect the inducible clindamycin resistance by d-test method. materials and methods a total of 209 clinical s. aureus isolates were collected and identified by conventional phenotypic tests. antibiotic susceptibility pattern was detected by disc diffusion method. d-test was done using clindamycin (2 μg) and erythromycin (15 μg) discs according to the protocols of clinical and laboratory standards institute (clsi). to detect methicillin resistant staphylococcus aureus (mrsa), oxacillin disc was used and the results were confirmed by detection of meca gene. results of all 209 clinical s. aureus isolates, 207 (99%) were resistant to amoxicillin. all isolates were susceptible to vancomycin and linezolid. the rate of clindamycin inducible resistance was 4% (n = 8). this phenotype was not observed in mrsa strains. there was no significant difference between methicillin resistant and susceptible strains. resistance to clindamycin and erythromycin was higher in mrsa strains. d+ phenotype was detected in 1 (1%) of all isolates. methicillin resistance was detected in 66 (32%) isolates by oxacillin disc and meca gene was detected by pcr.
منابع مشابه
Inducible clindamycin resistance in clinical isolates of Staphylococcus aureus.
Background: Staphylococcus aureus is one of the most important agents causing nosocomial infections. Inducible clindamycin resistance is an important concern, because common laboratory tests could not detect it. Objectives: The aim of this study was to detect the inducible clindamycin resistance by D-test method. Materials and Methods: A total of 209 clinical S. aureus isolates were collected a...
متن کاملInducible Clindamycin Resistance in Clinical Isolates of Staphylococcus aureus
Background: Staphylococcus aureus is one of the most important agents causing nosocomial infections. Inducible clindamycin resistance is an important concern, because common laboratory tests could not detect it. Objectives: The aim of this study was to detect the inducible clindamycin resistance by D-test method. Materials and Methods: A total of 209 clinical S. aureus isolates were collected a...
متن کاملInducible clindamycin resistance among Staphylococcus aureus isolates
Introduction: Clindamycin is considered an useful alternate drug in penicillin-allergic patients in the treatment of skin & soft tissue infections caused by Staphylococcus aureus. Staphylococcus spp. can be resistant to erythromycin through either erm or msr A genes. Strains with erm-mediated erythromycin resistance may possess inducible clindamycin resistance but may appear susceptible to clin...
متن کاملInducible Clindamycin Resistance in Staphylococcus aureus Isolated from Clinical Samples
Increasing frequency of methicillin resistant Staphylococcus aureus (MRSA) infections and changing patterns in antimicrobial resistance have led to renewed interest in the use of macrolide-lincosamide-streptogramin (MLS) antibiotics to treat such infections. Inducible macrolides, lincosamides, type B streptogramins (MLS(Bi)) resistance has to be identified to avoid clinical failure of clindamyc...
متن کاملinducible clindamycin resistance in clinical isolates of staphylococcus aureus due to erm genes, iran.
background and objectives: resistance to macrolide can be mediated by erm and msra genes in staphylococcus aureus . there are the evidences that show erm genes may be causative agent of inducible or constitutive resistance. the aim of this study was to investigate the incidence of inducible clindamycin resistance and determine the most frequency of erm and msr a genes among s. aureus isolates. ...
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عنوان ژورنال:
archives of clinical infectious diseasesجلد ۹، شماره ۲، صفحات ۰-۰
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